Monday, May 13, 2013

Non-inherited mutations account for many heart defects

May 12, 2013 ? New mutations that are absent in parents but appear in their offspring account for at least 10% of severe congenital heart disease, reveals a massive genomics study led, in part, by researchers at the Yale School of Medicine.

The analysis of all the genes of more than 1800 individuals found hundreds of mutations that can cause congenital heart disease, the most common form of birth defect that afflicts nearly 1% of all newborns. In particular, the study found frequent mutations in genes that modify histones, proteins that package DNA in the nucleus and orchestrate the timing and activation of genes crucial to development of the fetus.

The results of the study, part of the Pediatric Cardiac Genomics Consortium funded by the NIH's National Heart, Lung, and Blood Institute (NHLBI), were published online May 12 in the journal Nature.

"These findings provide new insight into the causes of this common congenital disease," said Richard Lifton, Sterling Professor and chair of the Department of Genetics, investigator for the Howard Hughes Medical Institute, and a senior author of the paper. "Most interestingly, the set of genes mutated in congenital heart disease unexpectedly overlapped with genes and pathways mutated in autism. These findings suggest there may be common pathways that underlie a wide range of common congenital diseases."

"This is an important piece of the puzzle that gives us a clearer picture of the causes of congenital heart disease," said Gary H. Gibbons, M.D., director of the NHLBI. "What this international, multi-center collaborative research effort was able to accomplish, in a small amount of time, is truly remarkable. The state-of-the-art sequencing techniques that were used are allowing us to push the envelope and envision a day when we may be able to better treat and eventually prevent congenital heart disease in the early stages of heart formation."

The mutations can occur at the same site, and both increase and decrease the modification histone proteins, said Martina Brueckner, professor of pediatrics and genetics at Yale and another senior author of the study. The results suggest a very sensitive developmental system that might also be influenced by environmental factors in development.

"These findings point to fundamental mechanisms that play a role in a wide range of congenital diseases," Lifton said.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/SrbtmWyEZRs/130512141210.htm

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Nineteen shot in New Orleans Mother's Day parade

(Reuters) - Nineteen people including two children were shot in New Orleans on Sunday when gunfire erupted at a Mother's Day parade, and city police said they were searching for three suspects.

Ten men, seven woman, a girl and a boy both age 10 were hit when wild gunfire opened up at about 1:45 p.m. as the parade marched along North Villere Street, according to police spokesman Garry Flot.

Two victims are undergoing surgery, Flot said in a statement. The children were grazed and are in good condition, he said. It was unclear if the victims were marching or bystanders watching the parade.

Police superintendent Ronal Serpas told reporters that officers saw three suspects running away, with one about age 18 to 22. No arrests were made.

"It appears that these two or three people, for reasons unknown to us, started shooting at, towards or in the crowd," Serpas said, adding that the incident was over in "just a couple of seconds."

Serpas said a witness reported hearing two different types of gunshot, which he said indicated two weapons were involved.

Mayor Mitch Landrieu called the shooting part of "the relentless drum beat of violence" on the streets of New Orleans.

"It's a culture of violence that has enveloped the city for a long, long period of time," Landrieu told a news conference outside University Hospital, where three victims were being treated for serious injuries.

Photographs of the aftermath in the Times-Picayune newspaper showed a man lying on his stomach beside a pool of blood, being helped by two bystanders. Other photos showed a man in shorts sitting on a cobbled street, his calf bleeding and covered with a bandana.

Emergency medical responders took 11 people to Interim LSU Public Hospital in New Orleans, according to hospital spokesman Marvin McGraw

Violent crime in New Orleans ranks above the national average in FBI surveys. A poll of city residents in 2010 found crime to be their greatest concern.

In February, four people were wounded in a shooting outside a nightclub in the city's French Quarter as crowds gathered for Mardi Gras celebrations.

(Reporting by Daniel Trotta; Brendan O'Brien and Tim Gaynor; Editing by Maureen Bavdek, Xavier Briand and Philip Barbara)

Source: http://news.yahoo.com/nineteen-shot-orleans-mothers-day-parade-001138827.html

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Sunday, May 12, 2013

Discrimination Complaints Filed Against Tucson, Where Mexican American Studies Was Shut Down

KVOA:

TUCSON-TUSD has reached a voluntary agreement to review its procedures to make sure it doesn't discriminate against minorities.

An organization called Civil Rights Center filed a complaint against the district saying it unfairly discriminated against Latinos.

Two out of three complaints against TUSD have been resolved, but the Civil Rights Center says their work here has just begun.

Read the whole story at KVOA

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Source: http://www.huffingtonpost.com/2013/05/12/discrimination-complaints_n_3262710.html

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What the national media is saying about LSU players preparing for NFL rookie mini-camps: links

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Saturday, May 11, 2013

Is there a morale crisis in the US nuclear force?

WASHINGTON (AP) ? Beyond the Air Force's embarrassing suspension of 17 nuclear missile launch officers lie two broader questions.

Do those entrusted with the world's most destructive weapons feel stuck in a dead-end career field, given the momentum toward more nuclear arms reductions? And is there a morale crisis among these officers?

This matters because the missiles ? 450 of them standing in below-ground silos, ready for launch at a moment's notice ? form a critical part of America's nuclear defenses. There is little room for error. Although none has ever been fired in anger, the risk of accidental launch or unauthorized intrusion is real.

In a rare look inside the secretive world of nuclear missiles, The Associated Press reported this past week that the deputy commander of operations for the 91st Missile Wing at Minot Air Force Base, N.D., complained to his officers about "rot" within their ranks.

In a confidential email obtained by the AP, Lt. Col. Jay Folds wrote of 17 launch officers, 10 percent of his force, being removed from duty for what he likened to incompetence. They are being given remedial training, with the goal of being back on duty within two months.

"If you have this many officers who failed, then how do you explain that and who should be held accountable for their failure?" Robert Gates, a former defense secretary, said Friday. "I think those questions clearly need to be answered."

When faced with similar questions during his Pentagon tenure, Gates fired the top two Air Force leaders in 2008. That followed a series of nuclear embarrassments, including the inadvertent transport of six nuclear-tipped missiles on a B-52 bomber, whose pilot did not know they were aboard when he flew from Minot to Barksdale Air Force Base, La.

Gates said in an interview Friday before addressing graduates of the University of South Carolina in Columbia, S.C., that he was disappointed by the latest revelations but confident that Minot's weapons were not in jeopardy.

The Minot missile wing is responsible for 150 Minuteman 3 missiles, one-third of the Air Force's entire ICBM force.

Inside the missile launch capsules, so called because of their pill-like shape, two officers stand watch, authorized to turn the keys enabled by secret launch codes if the presidential order ever comes. They are 60 feet underground, electronically linked to 10 silos, each with one armed Minuteman 3.

That is a lot of responsibility for the young lieutenants and captains that the Air Force puts in these jobs. It's also an enormous challenge for their commanders to keep them on track ? a challenge not always met.

In a March inspection the 91st wing was rated "marginal," the equivalent of a "D'' grade, when tested on launch skills.

Folds described a deeper problem, citing willful rule violations such as leaving open the multi-ton blast door to their launch compartment while one of the two crew members was asleep. Sleep breaks are authorized, but the open door is not, given the risk of losing control of the capsule to an unauthorized intruder.

Publicly, the Air Force insists that its missileers, as they are known within the service, are capable, trustworthy and committed. But Air Force Secretary Michael Donley also acknowledged in congressional testimony that he worries that talk of further shrinking the nation's nuclear force is having a "corrosive effect" on his troops.

Gen. Mark Welsh, the Air Force chief of staff, said at the same congressional hearing that it's understandable that young missile officers may be demoralized by the realization that theirs is a shrinking field.

"You say, 'My goodness, there's only three (missile wings in the entire Air Force). There's no opportunity there,'" Welsh said. "That's actually not the case, but that's the view when you're" in one of those units.

Bruce Blair, a former missile launch officer and now a national security scholar at Princeton University, said Friday that morale has dropped in part because the ICBM mission that originated in 1959, deterring the Soviet Union from attacking the U.S. or Europe, is less compelling than it was generations ago.

"This dead-end career is not the result of shrinking nuclear arsenals, but rather because the Cold War ended decades ago and because so few senior commander jobs exist within the missile specialty," Blair said. "Most crews can't wait to transfer out of missiles into faster-track careers such as space operations, but the Air Force doesn't make it easy."

Donley came close to blaming the White House for any malaise. He said that when officers see "the national leadership" contemplating more nuclear reductions "this does have a corrosive effect on our ability to maintain focus on this mission." He also said "critics or others" contribute to this when they suggest getting rid of the ICBM force entirely.

This touches on a sensitive problem for the Air Force, which is inclined to defend its nuclear turf even as President Barack Obama has made clear his view that it is time to end America's heavy reliance on nuclear weapons.

"The massive nuclear arsenal we inherited from the Cold War is poorly suited to today's threats, including nuclear terrorism," he said a year ago in Seoul. He noted that in 2011 he ordered his national security team to undertake a comprehensive review of nuclear forces and policies, which was completed last year.

"We can already say with confidence that we have more nuclear weapons than we need," Obama said.

The president is expected to announce this year his intention to make new nuclear reductions, and his defense secretary, Chuck Hagel, has publicly supported the eventual elimination of all of the Air Force's ICBMs. Hagel took that stand before he became Pentagon chief in February; he has not commented on it since then.

Hagel is scheduled to meet with Donley and Welsh on Monday to press for more answers on the lapses at Minot. He received a series of staff briefings on the matter in the days following publication of the AP story, and his press secretary, George Little, said Friday that Hagel "expects not to see this kind of problem again."

Concern over deterioration in the Air Force's nuclear mission is not new.

After Gates cleaned house in 2008, an outside advisory panel headed by former Defense Secretary James Schlesinger issued a scathing report. It concluded, "There has been an unambiguous, dramatic and unacceptable decline in the Air Force's commitment to perform the nuclear mission." It put the blame mainly on Air Force leaders, not young officers.

"The readiness of forces assigned the nuclear mission has seriously eroded," the report said, adding, "We must restore pride among those who are performing the Air Force nuclear mission."

Gates said Friday the onus is on Air Force leaders to avoid decay in the nuclear force, now and in the future.

"The challenge facing the Air Force leadership, no matter what the size of the nuclear arsenal, is how do you sustain the morale and the intensity of the men and women who manage the nuclear enterprise," Gates said. "That's not an easy thing, especially during terrible budget times that they're encountering right now."

___

Associated Press writer Meg Kinnard in Columbia, S.C., contributed to this report.

___

Robert Burns can be followed on Twitter at http://www.twitter.com/robertburnsAP

Source: http://news.yahoo.com/morale-crisis-us-nuclear-force-122512238.html

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Prince Harry salutes war dead at Arlington

Britain's Prince Harry greets attendees before a reception in the Prince's honor at the Ambassador's residence in Washington, Thursday, May 9, 2013. (AP Photo/Jim Lo Scalzo, Pool)

Britain's Prince Harry greets attendees before a reception in the Prince's honor at the Ambassador's residence in Washington, Thursday, May 9, 2013. (AP Photo/Jim Lo Scalzo, Pool)

England's Prince Harry visits Section 60 at Arlington National Cemetery, Friday, May 10, 2013. The British soldier-prince is spending most of his week in the U.S. honoring the wounded and the dead of war. (AP Photo/Charles Dharapak, Pool)

England's Prince Harry, right, speaks with US Army Major General Michael S. Linnington as he visits Section 60 of Arlington National Cemetery, where veterans of the wars in Iraq and Afghanistan are buried, in Virginia on May 10, 2013. (AP PHOTO/Nicholas Kamm, Pool)

British Ambassador Sir Peter Westmacott toasts Britain's Prince Harry at a dinner at the Ambassador's residence in Washington, Thursday, May 9, 2013. (AP Photo/Jim Lo Scalzo, Pool)

Britain's Prince Harry sits down to dinner at the Ambassador's residence in Washington, Thursday, May, 9, 2013, with Teresa Heinz, center left, wife of Secretary of State John Kerry, and the wife of the British Ambassador to the U.S. Lady Westmacott. (AP Photo/Jim Lo Scalzo, Pool)

(AP) ? Britain's Prince Harry saluted America's war dead in somber remembrance at Arlington National Cemetery on Friday, pausing, too, to place flowers on the tombstone of John F. Kennedy and visit the grave of a British World War II hero buried far from home.

There were none of the shrieking throngs that greeted his arrival Thursday on Capitol Hill at the opening of his weeklong U.S. visit, only solemn reflection and quiet ceremony.

Harry, a British Army captain who has served twice in Afghanistan, laid a wreath at the grave of another veteran of that war, Army soldier Michael L. Stansbery Jr., 21, of Mount Juliet, Tenn. He left a note reading: "To my comrades-in-arms of the United States of America, who have paid the ultimate sacrifice in the cause of freedom. Captain Harry Wales."

Stansbery, a Bronze Star and Purple Heart recipient, was killed July 30, 2010, by an improvised explosive device while on foot patrol in Afghanistan. His grave was chosen randomly for the prince's honor, among thousands marking the resting place of the fallen from the Afghanistan and Iraq wars.

Elizabeth Jennings of Arlington was in Section 60 tending to the grave of her brother-in-law and unaware that Prince Harry was just a few feet away until she was told. "I think it's really great that he's paying his respects," said Jennings, whose brother-in-law Navy Lt. Cmdr. Jonas Kelsall was killed in Afghanistan in 2011. "They're all brothers-in-arms."

After placing the wreath, Harry, in Army uniform with a light blue beret, saluted for several seconds, then walked through the rest of the section, pausing at the stones occasionally to read them.

On one knee, Harry placed flowers on JFK's tombstone near the eternal flame, then stood at attention and bowed his head. Kennedy was assassinated 50 years ago in November.

The prince also paid his respects at the grave of the British officer, Major Gen. Orde Wingate, who created the Chindits, troops who fought behind enemy lines against the Japanese in World War II, developing guerrilla tactics familiar in today's special forces. He died in the crash of a U.S. bomber in 1944. His remains and those of other crash victims, most American, were later moved to Arlington.

After Arlington, he was scheduled to meet fellow veterans being treated at Walter Reed National Military Medical Center, then fly to the 2013 Warrior Games in Colorado Springs, Colo., where more than 200 wounded servicemen and women from the U.S. and Britain will compete.

He opened his visit Thursday with the tour of an exhibition in Congress about land-mine removal, a cause embraced by his late mother, Princess Diana.

As he entered the rotunda of the Russell Senate Office Building near the Capitol, the prince was greeted by a roar and shouts of "Harry!" from a crowd of about 500, nearly all of them women. They filled a roped-off hallway and stairway with a view of the exhibit, hoisting their cellphones and tablets to get a picture. Harry didn't visibly react except to give what appeared to be a polite wave.

His escort, Sen. John McCain, said he told Harry "I've never seen, in all the years I've been here, such an unbalanced gender crowd."

The prince also made a previously unannounced visit to the White House, surprising military mothers and their children at an afternoon tea with Michelle Obama and Vice President Joe Biden's wife, Jill. The prince joined in helping the kids make Mother's Day gifts from tulip and rose bouquets, vegetable chips and edible dough jewelry.

For the prince, the Washington settings were a world away from the Afghanistan war zone, where he recently served for 20 weeks as a co-pilot gunner in an Apache attack helicopter. It was just as far removed from his hijinks in a Las Vegas hotel room last summer, when fuzzy photos got out of a naked Harry playing strip billiards.

At a glittering British diplomatic dinner Thursday night, Harry invoked the memory of his mother and her work with the mine-clearing HALO Trust charity, which he also supports.

"My mother, who believed passionately in this cause, would be proud of my association with HALO," he said. "In her special way, she adopted it as her own. She would join me ? along with all of you, I'm sure ? in praising HALO for the amazing work that it has done over the past quarter-century, and in hoping that one day soon its humanitarian work will be done."

Diana highlighted the trust's work when she was pictured wearing a face mask and protective clothing during a visit to a minefield being cleared by the organization in Angola in 1997. Her son said that at any one time, the group has 7,000 people deployed in the field, "striving to protect people and banish the fear that pervades the lives of millions around the world."

Harry will also visit parts of New Jersey afflicted by Superstorm Sandy and stop for events in New York City before capping his visit by playing in the Sentebale Polo Cup match in Greenwich, Conn., on Wednesday.

___

Associated Press writers Henry C. Jackson and Stacy A. Anderson contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-05-10-US-Prince-Harry/id-4b3310e58f8b454fa12b5ff84b8ccc08

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Gadget Lab Show: The Fitbit Flex Gets a Workout and Windows Goes Blue

Gadget Lab Show: The Fitbit Flex Gets a Workout and Windows Goes Blue
This week, staff writers Mat Honan and Roberto Baldwin get physical with the Fitbit Flex and share some good news about Windows 8.

Source: http://feedproxy.google.com/~r/GearFactor/~3/Uj47Dswec0Q/

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